Vergelijking

Semax vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

80714-61-0

25126-32-3

Molecuulmassa

813.92 g/mol

1143.29 g/mol

Halfwaardetijd

0.3 h

geen gegevens

Sequentie

Met-Glu-His-Phe-Pro-Gly-Pro

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Semax

Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Semax	Sincalide
Duitsland	Niet goedgekeurd	Onduidelijk
RU	Op recept	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Semax

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Sincalide

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Frequently asked questions

What is the difference between Semax and Sincalide?: Semax is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Semax or Sincalide?: The highest available evidence level is "Humane studie" for Semax and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Semax and Sincalide in Germany and the United States?: Duitsland: Semax — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Semax — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Semax

Sincalide

Duitsland

Niet goedgekeurd

Onduidelijk

Op recept

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Semax and Sincalide?

Semax is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Semax or Sincalide?

The highest available evidence level is "Humane studie" for Semax and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Semax and Sincalide in Germany and the United States?

Duitsland: Semax — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Semax — Niet goedgekeurd, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.