Confronto
Epitalon vs. Melanotan II
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
307297-39-8
121062-08-6
Peso molecolare
390.35 g/mol
1024.18 g/mol
Emivita
0.3 h
1 h
Sequenza
Ala-Glu-Asp-GlyAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Meccanismo d'azione
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Base di evidenze
Evidenza più alta
Studio sull'uomo
Studio sull'uomo
Studi
4
9
di cui sull'uomo
1
5
Effetti registrati
4
4
Contraddizioni aperte
1
1
Eventi avversi documentati
1
6
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Epitalon and Melanotan II?
- Epitalon is classified as "Ricerca (altro)", while Melanotan II is classified as "Ricerca (altro)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Melanotan II?
- The highest available evidence level is "Studio sull'uomo" for Epitalon and "Studio sull'uomo" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Melanotan II in Germany and the United States?
- Germania: Epitalon — Non approvato, Melanotan II — Non approvato. Stati Uniti: Epitalon — Non approvato, Melanotan II — Non approvato. These are factual summaries with source and review date on the individual pages.