Vergelijking

Epitalon vs. Melanotan II

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

307297-39-8

121062-08-6

Molecuulmassa

390.35 g/mol

1024.18 g/mol

Halfwaardetijd

0.3 h

1 h

Sequentie

Ala-Glu-Asp-Gly

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Werkingsmechanisme

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Melanotan II

Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Epitalon	Melanotan II
Australië	—	Verboden
Duitsland	Niet goedgekeurd	Niet goedgekeurd
Verenigd Koninkrijk	—	Verboden
RU	Alleen onderzoek	—
Verenigde Staten	Niet goedgekeurd	Niet goedgekeurd

Volledige vermeldingen

Epitalon

Volledige vermelding →

Melanotan II

Volledige vermelding →

Frequently asked questions

What is the difference between Epitalon and Melanotan II?: Epitalon is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Melanotan II?: The highest available evidence level is "Humane studie" for Epitalon and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Melanotan II in Germany and the United States?: Duitsland: Epitalon — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. Verenigde Staten: Epitalon — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Melanotan II

Australië

—

Verboden

Duitsland

Niet goedgekeurd

Verenigd Koninkrijk

—

Verboden

Alleen onderzoek

—

Verenigde Staten

Niet goedgekeurd

Frequently asked questions

What is the difference between Epitalon and Melanotan II?

Epitalon is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Melanotan II?

The highest available evidence level is "Humane studie" for Epitalon and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Melanotan II in Germany and the United States?

Duitsland: Epitalon — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. Verenigde Staten: Epitalon — Niet goedgekeurd, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.