Confronto
GHK-Cu vs. SNAP-8
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Cosmetico
Cosmetico
N. CAS
49557-75-7
868844-74-0
Peso molecolare
340.4 g/mol
1075.16 g/mol
Emivita
nessun dato
nessun dato
Sequenza
GHKAc-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2Meccanismo d'azione
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
SNAP-8
SNAP-8 is an octapeptide variant of Argireline. The sequence corresponds to the N-terminus of the SNAP-25 protein. As with Argireline, the postulated mechanism is competitive inhibition of the SNARE complex needed for acetylcholine vesicle fusion at the neuromuscular endplate. According to the manufacturer the two extra C-terminal amino acids increase SNARE-complex affinity — there are individual industry studies on this but no independent systematic confirmation.
Base di evidenze
Evidenza più alta
Studio sull'uomo
Studio sull'uomo
Studi
5
3
di cui sull'uomo
2
1
Effetti registrati
4
3
Contraddizioni aperte
1
0
Eventi avversi documentati
2
1
Stato legale
Voci complete
Frequently asked questions
- What is the difference between GHK-Cu and SNAP-8?
- GHK-Cu is classified as "Cosmetico", while SNAP-8 is classified as "Cosmetico". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. SNAP-8: Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapeptide-3) but with two additional C-terminal amino acids. Manufacturer marketing positions SNAP-8 as an 'improved' Argireline variant. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, GHK-Cu or SNAP-8?
- The highest available evidence level is "Studio sull'uomo" for GHK-Cu and "Studio sull'uomo" for SNAP-8. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of GHK-Cu and SNAP-8 in Germany and the United States?
- Germania: GHK-Cu — Non approvato, SNAP-8 — Non approvato. Stati Uniti: GHK-Cu — Non approvato, SNAP-8 — Non approvato. These are factual summaries with source and review date on the individual pages.