Comparison
GHK-Cu vs. SNAP-8
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Cosmetic
CAS no.
49557-75-7
868844-74-0
Molecular weight
340.4 g/mol
1075.16 g/mol
Half-life
no data
no data
Sequence
GHKAc-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2Mechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
SNAP-8
SNAP-8 is an octapeptide variant of Argireline. The sequence corresponds to the N-terminus of the SNAP-25 protein. As with Argireline, the postulated mechanism is competitive inhibition of the SNARE complex needed for acetylcholine vesicle fusion at the neuromuscular endplate. According to the manufacturer the two extra C-terminal amino acids increase SNARE-complex affinity — there are individual industry studies on this but no independent systematic confirmation.
Evidence base
Highest evidence
Human trial
Human trial
Studies
5
3
of which in humans
2
1
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
2
1
Legal status
Full entries
Frequently asked questions
- What is the difference between GHK-Cu and SNAP-8?
- GHK-Cu is classified as "Cosmetic", while SNAP-8 is classified as "Cosmetic". GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. SNAP-8: Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapeptide-3) but with two additional C-terminal amino acids. Manufacturer marketing positions SNAP-8 as an 'improved' Argireline variant. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, GHK-Cu or SNAP-8?
- The highest available evidence level is "Human trial" for GHK-Cu and "Human trial" for SNAP-8. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of GHK-Cu and SNAP-8 in Germany and the United States?
- Germany: GHK-Cu — Unapproved, SNAP-8 — Unapproved. United States: GHK-Cu — Unapproved, SNAP-8 — Unapproved. These are factual summaries with source and review date on the individual pages.