Confronto

Hexarelin vs. Ipamorelin

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Crescita

N. CAS

140703-51-1

170851-70-4

Peso molecolare

887.05 g/mol

711.86 g/mol

Emivita

0.9 h

2 h

Sequenza

His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2

Aib-His-D-2-Nal-D-Phe-Lys-NH2

Meccanismo d'azione

Hexarelin

Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.

Ipamorelin

Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.

Base di evidenze

Evidenza più alta

Studio sull'uomo

RCT sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Hexarelin	Ipamorelin
Australia	Vietato	—
Germania	Non approvato	Non approvato
Stati Uniti	Non approvato	Non approvato

Voci complete

Frequently asked questions

What is the difference between Hexarelin and Ipamorelin?: Hexarelin is classified as "Crescita", while Ipamorelin is classified as "Crescita". Hexarelin: Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine. Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Hexarelin or Ipamorelin?: The highest available evidence level is "Studio sull'uomo" for Hexarelin and "RCT sull'uomo" for Ipamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Hexarelin and Ipamorelin in Germany and the United States?: Germania: Hexarelin — Non approvato, Ipamorelin — Non approvato. Stati Uniti: Hexarelin — Non approvato, Ipamorelin — Non approvato. These are factual summaries with source and review date on the individual pages.

Country

Hexarelin

Ipamorelin

Australia

Vietato

—

Germania

Non approvato

Stati Uniti

Non approvato

Frequently asked questions

What is the difference between Hexarelin and Ipamorelin?

Hexarelin is classified as "Crescita", while Ipamorelin is classified as "Crescita". Hexarelin: Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine. Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Hexarelin or Ipamorelin?

The highest available evidence level is "Studio sull'uomo" for Hexarelin and "RCT sull'uomo" for Ipamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Hexarelin and Ipamorelin in Germany and the United States?

Germania: Hexarelin — Non approvato, Ipamorelin — Non approvato. Stati Uniti: Hexarelin — Non approvato, Ipamorelin — Non approvato. These are factual summaries with source and review date on the individual pages.