Comparison
Hexarelin vs. Ipamorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
140703-51-1
170851-70-4
Molecular weight
887.05 g/mol
711.86 g/mol
Half-life
0.9 h
2 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Aib-His-D-2-Nal-D-Phe-Lys-NH2Mechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
4
of which in humans
3
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1