Confronto
Melanotan II vs. Bremelanotide
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
121062-08-6
189691-06-3
Peso molecolare
1024.18 g/mol
1025.18 g/mol
Emivita
1 h
2.7 h
Sequenza
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHMeccanismo d'azione
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Base di evidenze
Evidenza più alta
Studio sull'uomo
RCT sull'uomo
Studi
9
5
di cui sull'uomo
5
5
Effetti registrati
4
3
Contraddizioni aperte
1
1
Eventi avversi documentati
6
2
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Melanotan II and Bremelanotide?
- Melanotan II is classified as "Ricerca (altro)", while Bremelanotide is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Bremelanotide?
- The highest available evidence level is "Studio sull'uomo" for Melanotan II and "RCT sull'uomo" for Bremelanotide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Bremelanotide in Germany and the United States?
- Germania: Melanotan II — Non approvato, Bremelanotide — Non approvato. Stati Uniti: Melanotan II — Non approvato, Bremelanotide — Su prescrizione. These are factual summaries with source and review date on the individual pages.