Vergelijking
Melanotan II vs. Bremelanotide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
121062-08-6
189691-06-3
Molecuulmassa
1024.18 g/mol
1025.18 g/mol
Halfwaardetijd
1 h
2.7 h
Sequentie
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHWerkingsmechanisme
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
9
5
waarvan bij mensen
5
5
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
6
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Melanotan II and Bremelanotide?
- Melanotan II is classified as "Onderzoek (overig)", while Bremelanotide is classified as "Onderzoek (overig)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Bremelanotide?
- The highest available evidence level is "Humane studie" for Melanotan II and "Humane RCT" for Bremelanotide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Bremelanotide in Germany and the United States?
- Duitsland: Melanotan II — Niet goedgekeurd, Bremelanotide — Niet goedgekeurd. Verenigde Staten: Melanotan II — Niet goedgekeurd, Bremelanotide — Op recept. These are factual summaries with source and review date on the individual pages.