Confronto
Octreotide vs. Semax
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
83150-76-9
80714-61-0
Peso molecolare
1019.24 g/mol
813.92 g/mol
Emivita
1.7 h
0.3 h
Sequenza
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)Met-Glu-His-Phe-Pro-Gly-ProMeccanismo d'azione
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Base di evidenze
Evidenza più alta
RCT sull'uomo
Studio sull'uomo
Studi
5
4
di cui sull'uomo
4
2
Effetti registrati
3
3
Contraddizioni aperte
1
1
Eventi avversi documentati
2
1
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Octreotide and Semax?
- Octreotide is classified as "Ricerca (altro)", while Semax is classified as "Ricerca (altro)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Semax?
- The highest available evidence level is "RCT sull'uomo" for Octreotide and "Studio sull'uomo" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Semax in Germany and the United States?
- Germania: Octreotide — Su prescrizione, Semax — Non approvato. Stati Uniti: Octreotide — Su prescrizione, Semax — Non approvato. These are factual summaries with source and review date on the individual pages.