Vergelijking
Octreotide vs. Semax
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
83150-76-9
80714-61-0
Molecuulmassa
1019.24 g/mol
813.92 g/mol
Halfwaardetijd
1.7 h
0.3 h
Sequentie
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)Met-Glu-His-Phe-Pro-Gly-ProWerkingsmechanisme
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
4
waarvan bij mensen
4
2
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Octreotide and Semax?
- Octreotide is classified as "Onderzoek (overig)", while Semax is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Semax?
- The highest available evidence level is "Humane RCT" for Octreotide and "Humane studie" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Semax in Germany and the United States?
- Duitsland: Octreotide — Op recept, Semax — Niet goedgekeurd. Verenigde Staten: Octreotide — Op recept, Semax — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.