Vergelijking

Afamelanotide vs. Terlipressin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

75921-69-6

14636-12-5

Molecuulmassa

1646.87 g/mol

1227.37 g/mol

Halfwaardetijd

12 h

geen gegevens

Sequentie

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

geen gegevens

Werkingsmechanisme

Afamelanotide

Afamelanotide is a synthetic analogue of α-melanocyte-stimulating hormone. It differs from native α-MSH by two substitutions — norleucine at position 4 and D-phenylalanine at position 7 — which make it metabolically more stable and more potent. As an agonist at the melanocortin-1 receptor (MC1R) on melanocytes, it activates adenylate cyclase, raises cAMP and increases tyrosinase activity via the transcription factor MITF. This shifts pigment synthesis toward eumelanin, which absorbs UV and visible light and has antioxidant properties — the presumed mechanism of photoprotection in EPP.

Terlipressin

Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Afamelanotide	Terlipressin
Duitsland	Op recept	Op recept
EU	Op recept	—
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Afamelanotide

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Terlipressin

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Frequently asked questions

What is the difference between Afamelanotide and Terlipressin?: Afamelanotide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Afamelanotide or Terlipressin?: The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Afamelanotide and Terlipressin in Germany and the United States?: Duitsland: Afamelanotide — Op recept, Terlipressin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Afamelanotide

Terlipressin

Duitsland

Op recept

—

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Afamelanotide and Terlipressin?

Afamelanotide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Afamelanotide: Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 receptor agonist. Unlike most peptides covered here, it is a regularly approved medicine: EMA approval in 2014/2015, FDA approval in 2019, in each case as a subcutaneous implant for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP). It promotes eumelanin formation in the skin. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Afamelanotide or Terlipressin?

The highest available evidence level is "Humane RCT" for Afamelanotide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Afamelanotide and Terlipressin in Germany and the United States?

Duitsland: Afamelanotide — Op recept, Terlipressin — Op recept. Verenigde Staten: Afamelanotide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.