Vergelijking
Cagrilintide vs. Petrelintide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
1415456-99-3
geen gegevens
Molecuulmassa
4253.7 g/mol
geen gegevens
Halfwaardetijd
168 h
geen gegevens
Sequentie
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYgeen gegevens
Werkingsmechanisme
Cagrilintide
Cagrilintide binds amylin receptors (AMY1, AMY3, formed by the calcitonin receptor plus RAMP proteins). Activation delays gastric emptying, inhibits postprandial glucagon secretion and modulates central satiety signalling via area postrema neurons. An acyl modification enables albumin binding and thereby weekly dosing.
Petrelintide
As an amylin analogue, petrelintide acts through amylin receptors, promoting satiety and slowed gastric emptying — a satiety pathway independent of the GLP-1 axis.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
1
waarvan bij mensen
3
1
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Cagrilintide and Petrelintide?
- Cagrilintide is classified as "Metabool", while Petrelintide is classified as "Metabool". Cagrilintide: Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and type 2 diabetes are ongoing. No marketing approval yet. Petrelintide: Petrelintide is a long-acting amylin analogue (Zealand Pharma, with Roche) for once-weekly subcutaneous use — developed for weight management with a focus on strong tolerability. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cagrilintide or Petrelintide?
- The highest available evidence level is "Humane RCT" for Cagrilintide and "Humane RCT" for Petrelintide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cagrilintide and Petrelintide in Germany and the United States?
- Duitsland: Cagrilintide — Niet goedgekeurd, Petrelintide — Niet goedgekeurd. Verenigde Staten: Cagrilintide — Niet goedgekeurd, Petrelintide — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.