Vergelijking
CagriSema vs. Exenatide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
geen gegevens
141758-74-9
Molecuulmassa
geen gegevens
4186.6 g/mol
Halfwaardetijd
geen gegevens
2.4 h
Sequentie
geen gegevens
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSWerkingsmechanisme
CagriSema
CagriSema combines two satiety pathways in one weekly injection: the amylin analogue cagrilintide and the GLP-1 agonist semaglutide. Both suppress appetite and food intake — together more than either component alone.
Exenatide
Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV cleavage and extends the half-life from native GLP-1 (minutes) to about 2.4 hours. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon and delays gastric emptying.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
1
5
waarvan bij mensen
1
4
Geregistreerde effecten
2
3
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between CagriSema and Exenatide?
- CagriSema is classified as "Metabool", while Exenatide is classified as "Metabool". CagriSema: CagriSema is a fixed-dose combination of the amylin analogue cagrilintide and the GLP-1 agonist semaglutide (Novo Nordisk), in late-stage development for obesity and type 2 diabetes. Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, CagriSema or Exenatide?
- The highest available evidence level is "Humane RCT" for CagriSema and "Humane RCT" for Exenatide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of CagriSema and Exenatide in Germany and the United States?
- Duitsland: CagriSema — Niet goedgekeurd, Exenatide — Op recept. Verenigde Staten: CagriSema — Niet goedgekeurd, Exenatide — Op recept. These are factual summaries with source and review date on the individual pages.