Vergelijking
Cetrorelix vs. DSIP
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
120287-85-6
62568-57-4
Molecuulmassa
1431.06 g/mol
848.81 g/mol
Halfwaardetijd
geen gegevens
0.1 h
Sequentie
geen gegevens
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-GluWerkingsmechanisme
Cetrorelix
Cetrorelix competitively and immediately blocks the pituitary GnRH receptor, rapidly suppressing LH and FSH release — without the initial hormone surge ('flare') of GnRH agonists.
DSIP
DSIP was described in 1977 by the Schoenenberger-Monnier group in Basel as a blood-borne substance reported to induce EEG changes similar to delta sleep in animal models. The exact mechanism remains undefined to this day: no defined receptor, proposed modulation of opioid, GABAergic and glutamatergic systems. Most mechanistic findings stem from preclinical studies of the 1980s and 1990s and were later subjected to contested replication attempts.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
0
4
waarvan bij mensen
0
1
Geregistreerde effecten
2
3
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Cetrorelix and DSIP?
- Cetrorelix is classified as "Onderzoek (overig)", while DSIP is classified as "Onderzoek (overig)". Cetrorelix: Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during controlled ovarian stimulation. DSIP: Synthetic nonapeptide isolated in 1977 by Guido Monnier and Marcel Schoenenberger from the blood of rabbits in delta sleep. Despite the name, the role in sleep regulation is contested and not confirmed by Western RCTs in larger populations. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cetrorelix or DSIP?
- The highest available evidence level is "Humane RCT" for Cetrorelix and "Humane studie" for DSIP. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cetrorelix and DSIP in Germany and the United States?
- Duitsland: Cetrorelix — Op recept, DSIP — Niet goedgekeurd. Verenigde Staten: Cetrorelix — Op recept, DSIP — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.