Vergelijking

Epitalon vs. Pasireotid

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

307297-39-8

396091-73-9

Molecuulmassa

390.35 g/mol

1047.21 g/mol

Halfwaardetijd

0.3 h

geen gegevens

Sequentie

Ala-Glu-Asp-Gly

geen gegevens

Werkingsmechanisme

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Pasireotid

Pasireotide binds more broadly than older somatostatin analogs (SSTR1/2/3/5) with particularly high affinity for SSTR5. This suppresses, among others, ACTH release in Cushing's disease and GH release in acromegaly.

Bewijsbasis

Hoogste bewijs

Humane studie

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Epitalon	Pasireotid
Duitsland	Niet goedgekeurd	Op recept
RU	Alleen onderzoek	—
Verenigde Staten	Niet goedgekeurd	Op recept

Volledige vermeldingen

Epitalon

Volledige vermelding →

Pasireotid

Volledige vermelding →

Frequently asked questions

What is the difference between Epitalon and Pasireotid?: Epitalon is classified as "Onderzoek (overig)", while Pasireotid is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Pasireotid: Pasireotide is a multireceptor somatostatin analog binding to four of the five somatostatin receptors (especially SSTR5). It is approved for Cushing's disease and acromegaly. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Pasireotid?: The highest available evidence level is "Humane studie" for Epitalon and "Humane RCT" for Pasireotid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Pasireotid in Germany and the United States?: Duitsland: Epitalon — Niet goedgekeurd, Pasireotid — Op recept. Verenigde Staten: Epitalon — Niet goedgekeurd, Pasireotid — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Pasireotid

Duitsland

Niet goedgekeurd

Op recept

Alleen onderzoek

—

Verenigde Staten

Niet goedgekeurd

Op recept

Frequently asked questions

What is the difference between Epitalon and Pasireotid?

Epitalon is classified as "Onderzoek (overig)", while Pasireotid is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Pasireotid: Pasireotide is a multireceptor somatostatin analog binding to four of the five somatostatin receptors (especially SSTR5). It is approved for Cushing's disease and acromegaly. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Pasireotid?

The highest available evidence level is "Humane studie" for Epitalon and "Humane RCT" for Pasireotid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Pasireotid in Germany and the United States?

Duitsland: Epitalon — Niet goedgekeurd, Pasireotid — Op recept. Verenigde Staten: Epitalon — Niet goedgekeurd, Pasireotid — Op recept. These are factual summaries with source and review date on the individual pages.