Vergelijking
Epitalon vs. Semax
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
307297-39-8
80714-61-0
Molecuulmassa
390.35 g/mol
813.92 g/mol
Halfwaardetijd
0.3 h
0.3 h
Sequentie
Ala-Glu-Asp-GlyMet-Glu-His-Phe-Pro-Gly-ProWerkingsmechanisme
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane studie
Studies
4
4
waarvan bij mensen
1
2
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Epitalon and Semax?
- Epitalon is classified as "Onderzoek (overig)", while Semax is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Semax?
- The highest available evidence level is "Humane studie" for Epitalon and "Humane studie" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Semax in Germany and the United States?
- Duitsland: Epitalon — Niet goedgekeurd, Semax — Niet goedgekeurd. Verenigde Staten: Epitalon — Niet goedgekeurd, Semax — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.