Comparison
Epitalon vs. Semax
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
307297-39-8
80714-61-0
Molecular weight
390.35 g/mol
813.92 g/mol
Half-life
0.3 h
0.3 h
Sequence
Ala-Glu-Asp-GlyMet-Glu-His-Phe-Pro-Gly-ProMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
1