Vergelijking
Ganirelix vs. Melanotan II
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
123246-29-7
121062-08-6
Molecuulmassa
1570.3 g/mol
1024.18 g/mol
Halfwaardetijd
geen gegevens
1 h
Sequentie
geen gegevens
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Werkingsmechanisme
Ganirelix
Ganirelix competitively and reversibly binds the pituitary GnRH receptor, rapidly suppressing LH (and, less so, FSH) release — without the initial hormone 'flare' of GnRH agonists.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
1
9
waarvan bij mensen
1
5
Geregistreerde effecten
2
4
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
6
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Ganirelix and Melanotan II?
- Ganirelix is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Ganirelix: Ganirelix is a synthetic decapeptide and GnRH antagonist. In assisted reproduction (IVF) it prevents the premature LH surge during controlled ovarian stimulation. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Ganirelix or Melanotan II?
- The highest available evidence level is "Humane RCT" for Ganirelix and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Ganirelix and Melanotan II in Germany and the United States?
- Duitsland: Ganirelix — Op recept, Melanotan II — Niet goedgekeurd. Verenigde Staten: Ganirelix — Op recept, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.