Comparison
Ganirelix vs. Melanotan II
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
123246-29-7
121062-08-6
Molecular weight
1570.3 g/mol
1024.18 g/mol
Half-life
no data
1 h
Sequence
no data
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Mechanism of action
Ganirelix
Ganirelix competitively and reversibly binds the pituitary GnRH receptor, rapidly suppressing LH (and, less so, FSH) release — without the initial hormone 'flare' of GnRH agonists.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
1
9
of which in humans
1
5
Effects recorded
2
4
Open conflicts
0
1
Documented adverse events
1
6
Legal status
Full entries
Frequently asked questions
- What is the difference between Ganirelix and Melanotan II?
- Ganirelix is classified as "Research other", while Melanotan II is classified as "Research other". Ganirelix: Ganirelix is a synthetic decapeptide and GnRH antagonist. In assisted reproduction (IVF) it prevents the premature LH surge during controlled ovarian stimulation. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Ganirelix or Melanotan II?
- The highest available evidence level is "Human RCT" for Ganirelix and "Human trial" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Ganirelix and Melanotan II in Germany and the United States?
- Germany: Ganirelix — Prescription, Melanotan II — Unapproved. United States: Ganirelix — Prescription, Melanotan II — Unapproved. These are factual summaries with source and review date on the individual pages.