Vergelijking
Icatibant vs. Melanotan II
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
138614-30-9
121062-08-6
Molecuulmassa
1304.52 g/mol
1024.18 g/mol
Halfwaardetijd
geen gegevens
1 h
Sequentie
geen gegevens
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Werkingsmechanisme
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
1
9
waarvan bij mensen
1
5
Geregistreerde effecten
1
4
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
1
6
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Icatibant and Melanotan II?
- Icatibant is classified as "Onderzoek (overig)", while Melanotan II is classified as "Onderzoek (overig)". Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Icatibant or Melanotan II?
- The highest available evidence level is "Humane RCT" for Icatibant and "Humane studie" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Icatibant and Melanotan II in Germany and the United States?
- Duitsland: Icatibant — Op recept, Melanotan II — Niet goedgekeurd. Verenigde Staten: Icatibant — Op recept, Melanotan II — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.