Comparison
Icatibant vs. Melanotan II
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
138614-30-9
121062-08-6
Molecular weight
1304.52 g/mol
1024.18 g/mol
Half-life
no data
1 h
Sequence
no data
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Mechanism of action
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
1
9
of which in humans
1
5
Effects recorded
1
4
Open conflicts
0
1
Documented adverse events
1
6
Legal status
Full entries
Frequently asked questions
- What is the difference between Icatibant and Melanotan II?
- Icatibant is classified as "Research other", while Melanotan II is classified as "Research other". Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Icatibant or Melanotan II?
- The highest available evidence level is "Human RCT" for Icatibant and "Human trial" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Icatibant and Melanotan II in Germany and the United States?
- Germany: Icatibant — Prescription, Melanotan II — Unapproved. United States: Icatibant — Prescription, Melanotan II — Unapproved. These are factual summaries with source and review date on the individual pages.