Vergelijking

Linaclotid vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

851199-59-2

25126-32-3

Molecuulmassa

1526.74 g/mol

1143.29 g/mol

Halfwaardetijd

geen gegevens

Sequentie

geen gegevens

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Linaclotid

Linaclotide activates the guanylate cyclase-C receptor on the luminal surface of the intestinal epithelium. This raises cyclic GMP (cGMP), increases secretion of chloride and bicarbonate into the lumen, raises stool fluid content and accelerates transit; pain signaling is also modulated.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Linaclotid	Sincalide
Duitsland	Op recept	Onduidelijk
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Linaclotid

Volledige vermelding →

Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Linaclotid and Sincalide?: Linaclotid is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Linaclotid: Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Linaclotid or Sincalide?: The highest available evidence level is "Humane RCT" for Linaclotid and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Linaclotid and Sincalide in Germany and the United States?: Duitsland: Linaclotid — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Linaclotid — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Linaclotid

Sincalide

Duitsland

Op recept

Onduidelijk

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Linaclotid and Sincalide?

Linaclotid is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Linaclotid: Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Linaclotid or Sincalide?

The highest available evidence level is "Humane RCT" for Linaclotid and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Linaclotid and Sincalide in Germany and the United States?

Duitsland: Linaclotid — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Linaclotid — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.