Comparison
Linaclotid vs. Sincalide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
851199-59-2
25126-32-3
Molecular weight
1526.74 g/mol
1143.29 g/mol
Half-life
no data
no data
Sequence
no data
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Mechanism of action
Linaclotid
Linaclotide activates the guanylate cyclase-C receptor on the luminal surface of the intestinal epithelium. This raises cyclic GMP (cGMP), increases secretion of chloride and bicarbonate into the lumen, raises stool fluid content and accelerates transit; pain signaling is also modulated.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Evidence base
Highest evidence
Human RCT
Human trial
Studies
0
0
of which in humans
0
0
Effects recorded
2
1
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Linaclotid and Sincalide?
- Linaclotid is classified as "Research other", while Sincalide is classified as "Research other". Linaclotid: Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Linaclotid or Sincalide?
- The highest available evidence level is "Human RCT" for Linaclotid and "Human trial" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Linaclotid and Sincalide in Germany and the United States?
- Germany: Linaclotid — Prescription, Sincalide — Unclear. United States: Linaclotid — Prescription, Sincalide — Prescription. These are factual summaries with source and review date on the individual pages.