Vergelijking
Matrixyl vs. SNAP-8
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Cosmetisch
Cosmetisch
CAS-nr.
214047-00-4
868844-74-0
Molecuulmassa
802.06 g/mol
1075.16 g/mol
Halfwaardetijd
geen gegevens
geen gegevens
Sequentie
Palmitoyl-Lys-Thr-Thr-Lys-SerAc-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2Werkingsmechanisme
Matrixyl
KTTKS is a fragment of the procollagen I sequence and appears to be part of a feedback mechanism in fibroblasts: elevated concentrations signal intact collagen synthesis and downregulate new synthesis, while low concentrations stimulate it. In cell-culture studies, stimulation of collagen types I/III, elastin, fibronectin and glycosaminoglycans has been documented. The palmitoyl modification is intended to improve skin penetration; effect at the site of action (dermal fibroblasts) depends on permeation.
SNAP-8
SNAP-8 is an octapeptide variant of Argireline. The sequence corresponds to the N-terminus of the SNAP-25 protein. As with Argireline, the postulated mechanism is competitive inhibition of the SNARE complex needed for acetylcholine vesicle fusion at the neuromuscular endplate. According to the manufacturer the two extra C-terminal amino acids increase SNARE-complex affinity — there are individual industry studies on this but no independent systematic confirmation.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
3
waarvan bij mensen
2
1
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
0
0
Gedocumenteerde bijwerkingen
1
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Matrixyl and SNAP-8?
- Matrixyl is classified as "Cosmetisch", while SNAP-8 is classified as "Cosmetisch". Matrixyl: Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine. SNAP-8: Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapeptide-3) but with two additional C-terminal amino acids. Manufacturer marketing positions SNAP-8 as an 'improved' Argireline variant. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Matrixyl or SNAP-8?
- The highest available evidence level is "Humane RCT" for Matrixyl and "Humane studie" for SNAP-8. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Matrixyl and SNAP-8 in Germany and the United States?
- Duitsland: Matrixyl — Niet goedgekeurd, SNAP-8 — Niet goedgekeurd. Verenigde Staten: Matrixyl — Niet goedgekeurd, SNAP-8 — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.