Vergelijking

Octreotide vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

83150-76-9

25126-32-3

Molecuulmassa

1019.24 g/mol

1143.29 g/mol

Halfwaardetijd

1.7 h

geen gegevens

Sequentie

D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Octreotide

Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Octreotide	Sincalide
Duitsland	Op recept	Onduidelijk
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Octreotide

Volledige vermelding →

Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Octreotide and Sincalide?: Octreotide is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Octreotide or Sincalide?: The highest available evidence level is "Humane RCT" for Octreotide and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Octreotide and Sincalide in Germany and the United States?: Duitsland: Octreotide — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Octreotide — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Octreotide

Sincalide

Duitsland

Op recept

Onduidelijk

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Octreotide and Sincalide?

Octreotide is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Octreotide or Sincalide?

The highest available evidence level is "Humane RCT" for Octreotide and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Octreotide and Sincalide in Germany and the United States?

Duitsland: Octreotide — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Octreotide — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.