Comparison
Octreotide vs. Sincalide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
83150-76-9
25126-32-3
Molecular weight
1019.24 g/mol
1143.29 g/mol
Half-life
1.7 h
no data
Sequence
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Mechanism of action
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Evidence base
Highest evidence
Human RCT
Human trial
Studies
5
0
of which in humans
4
0
Effects recorded
3
1
Open conflicts
1
0
Documented adverse events
2
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Octreotide and Sincalide?
- Octreotide is classified as "Research other", while Sincalide is classified as "Research other". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Sincalide?
- The highest available evidence level is "Human RCT" for Octreotide and "Human trial" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Sincalide in Germany and the United States?
- Germany: Octreotide — Prescription, Sincalide — Unclear. United States: Octreotide — Prescription, Sincalide — Prescription. These are factual summaries with source and review date on the individual pages.