Vergelijking

Octreotide vs. Terlipressin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

83150-76-9

14636-12-5

Molecuulmassa

1019.24 g/mol

1227.37 g/mol

Halfwaardetijd

1.7 h

geen gegevens

Sequentie

D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)

geen gegevens

Werkingsmechanisme

Octreotide

Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).

Terlipressin

Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Octreotide	Terlipressin
Duitsland	Op recept	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Octreotide

Volledige vermelding →

Terlipressin

Volledige vermelding →

Frequently asked questions

What is the difference between Octreotide and Terlipressin?: Octreotide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Octreotide or Terlipressin?: The highest available evidence level is "Humane RCT" for Octreotide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Octreotide and Terlipressin in Germany and the United States?: Duitsland: Octreotide — Op recept, Terlipressin — Op recept. Verenigde Staten: Octreotide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Octreotide

Terlipressin

Duitsland

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Octreotide and Terlipressin?

Octreotide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Octreotide or Terlipressin?

The highest available evidence level is "Humane RCT" for Octreotide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Octreotide and Terlipressin in Germany and the United States?

Duitsland: Octreotide — Op recept, Terlipressin — Op recept. Verenigde Staten: Octreotide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.