Vergelijking
Octreotide vs. Triptorelin
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
83150-76-9
57773-63-4
Molecuulmassa
1019.24 g/mol
1311.45 g/mol
Halfwaardetijd
1.7 h
3 h
Sequentie
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Werkingsmechanisme
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
5
4
waarvan bij mensen
4
4
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
3
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Octreotide and Triptorelin?
- Octreotide is classified as "Onderzoek (overig)", while Triptorelin is classified as "Onderzoek (overig)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Triptorelin?
- The highest available evidence level is "Humane RCT" for Octreotide and "Humane RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Triptorelin in Germany and the United States?
- Duitsland: Octreotide — Op recept, Triptorelin — Op recept. Verenigde Staten: Octreotide — Op recept, Triptorelin — Op recept. These are factual summaries with source and review date on the individual pages.