Vergelijking

Oxytocin vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

50-56-6

25126-32-3

Molecuulmassa

1007.19 g/mol

1143.29 g/mol

Halfwaardetijd

0.05 h

geen gegevens

Sequentie

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Oxytocin

Oxytocin is synthesised in the hypothalamus and released via the posterior pituitary. Peripherally it binds the oxytocin receptor, a G-protein-coupled receptor, and through the phospholipase-C cascade and calcium release triggers contraction of uterine smooth muscle and milk ejection — the pharmacological basis of the obstetric approval. Centrally, oxytocin acts as a neuromodulator and has been linked to social bonding, trust and modulation of stress and anxiety circuits. Its central effects in humans are mechanistically incompletely understood, particularly because it is unclear to what extent peripherally or intranasally administered oxytocin crosses the blood-brain barrier.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Oxytocin	Sincalide
Duitsland	Op recept	Onduidelijk
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Oxytocin

Volledige vermelding →

Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Oxytocin and Sincalide?: Oxytocin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Oxytocin: Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Oxytocin or Sincalide?: The highest available evidence level is "Humane RCT" for Oxytocin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Oxytocin and Sincalide in Germany and the United States?: Duitsland: Oxytocin — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Oxytocin — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Oxytocin

Sincalide

Duitsland

Op recept

Onduidelijk

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Oxytocin and Sincalide?

Oxytocin is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Oxytocin: Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Oxytocin or Sincalide?

The highest available evidence level is "Humane RCT" for Oxytocin and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Oxytocin and Sincalide in Germany and the United States?

Duitsland: Oxytocin — Op recept, Sincalide — Onduidelijk. Verenigde Staten: Oxytocin — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.