Vergelijking
Plecanatid vs. Teduglutid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
467426-54-6
197922-42-2
Molecuulmassa
1682 g/mol
3752.13 g/mol
Halfwaardetijd
geen gegevens
geen gegevens
Sequentie
geen gegevens
geen gegevens
Werkingsmechanisme
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
0
2
waarvan bij mensen
0
2
Geregistreerde effecten
2
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Plecanatid and Teduglutid?
- Plecanatid is classified as "Onderzoek (overig)", while Teduglutid is classified as "Onderzoek (overig)". Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Plecanatid or Teduglutid?
- The highest available evidence level is "Humane RCT" for Plecanatid and "Humane RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Plecanatid and Teduglutid in Germany and the United States?
- Duitsland: Plecanatid — Niet goedgekeurd, Teduglutid — Op recept. Verenigde Staten: Plecanatid — Op recept, Teduglutid — Op recept. These are factual summaries with source and review date on the individual pages.