Vergelijking
Pramlintid vs. Survodutide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
151126-32-8
2179963-22-7
Molecuulmassa
3949.4 g/mol
4727 g/mol
Halfwaardetijd
geen gegevens
168 h
Sequentie
geen gegevens
modifiziertes 29-Aminosäuren-Peptid mit FettsäureseitenketteWerkingsmechanisme
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Survodutide
Survodutide is a dual agonist at the GLP-1 and glucagon receptors. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secretion at high blood glucose and modulation of satiety. The glucagon component raises basal energy expenditure via hepatic and brown adipocyte effects. A fatty-acid side chain enables albumin binding and weekly dosing.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
0
4
waarvan bij mensen
0
4
Geregistreerde effecten
2
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Pramlintid and Survodutide?
- Pramlintid is classified as "Metabool", while Survodutide is classified as "Metabool". Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. Survodutide: Synthetic peptide that simultaneously activates the GLP-1 and glucagon receptors. Developed by Boehringer Ingelheim and Zealand Pharma; in phase-3 trials for obesity (SYNCHRONIZE) and MASH. No marketing approval yet. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Pramlintid or Survodutide?
- The highest available evidence level is "Humane RCT" for Pramlintid and "Humane RCT" for Survodutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Pramlintid and Survodutide in Germany and the United States?
- Duitsland: Pramlintid — Niet goedgekeurd, Survodutide — Niet goedgekeurd. Verenigde Staten: Pramlintid — Op recept, Survodutide — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.