Vergelijking
Bremelanotide vs. Semax
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
189691-06-3
80714-61-0
Molecuulmassa
1025.18 g/mol
813.92 g/mol
Halfwaardetijd
2.7 h
0.3 h
Sequentie
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OHMet-Glu-His-Phe-Pro-Gly-ProWerkingsmechanisme
Bremelanotide
Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
4
waarvan bij mensen
5
2
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Bremelanotide and Semax?
- Bremelanotide is classified as "Onderzoek (overig)", while Semax is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Bremelanotide or Semax?
- The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Bremelanotide and Semax in Germany and the United States?
- Duitsland: Bremelanotide — Niet goedgekeurd, Semax — Niet goedgekeurd. Verenigde Staten: Bremelanotide — Op recept, Semax — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.