Vergelijking

Bremelanotide vs. Sincalide

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

189691-06-3

25126-32-3

Molecuulmassa

1025.18 g/mol

1143.29 g/mol

Halfwaardetijd

2.7 h

geen gegevens

Sequentie

Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Werkingsmechanisme

Bremelanotide

Bremelanotide is a cyclic peptide that binds non-selectively to melanocortin receptors (MC1R through MC5R) — with highest affinity at MC4R in the central nervous system. The precise role of MC4R activation in sexual behaviour is not fully understood; animal data show effects on hypothalamic circuits. Peripheral effects (blood pressure, hyperpigmentation) are attributed to MC1R/MC2R.

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Bewijsbasis

Hoogste bewijs

Humane RCT

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Bremelanotide	Sincalide
Australië	Beperkt	—
Duitsland	Niet goedgekeurd	Onduidelijk
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Bremelanotide

Volledige vermelding →

Sincalide

Volledige vermelding →

Frequently asked questions

What is the difference between Bremelanotide and Sincalide?: Bremelanotide is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Bremelanotide or Sincalide?: The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Bremelanotide and Sincalide in Germany and the United States?: Duitsland: Bremelanotide — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Bremelanotide — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Bremelanotide

Sincalide

Australië

Beperkt

—

Duitsland

Niet goedgekeurd

Onduidelijk

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Bremelanotide and Sincalide?

Bremelanotide is classified as "Onderzoek (overig)", while Sincalide is classified as "Onderzoek (overig)". Bremelanotide: Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Bremelanotide or Sincalide?

The highest available evidence level is "Humane RCT" for Bremelanotide and "Humane studie" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Bremelanotide and Sincalide in Germany and the United States?

Duitsland: Bremelanotide — Niet goedgekeurd, Sincalide — Onduidelijk. Verenigde Staten: Bremelanotide — Op recept, Sincalide — Op recept. These are factual summaries with source and review date on the individual pages.