Vergelijking
Semax vs. Teduglutid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
80714-61-0
197922-42-2
Molecuulmassa
813.92 g/mol
3752.13 g/mol
Halfwaardetijd
0.3 h
geen gegevens
Sequentie
Met-Glu-His-Phe-Pro-Gly-Progeen gegevens
Werkingsmechanisme
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
4
2
waarvan bij mensen
2
2
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Semax and Teduglutid?
- Semax is classified as "Onderzoek (overig)", while Teduglutid is classified as "Onderzoek (overig)". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Semax or Teduglutid?
- The highest available evidence level is "Humane studie" for Semax and "Humane RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Semax and Teduglutid in Germany and the United States?
- Duitsland: Semax — Niet goedgekeurd, Teduglutid — Op recept. Verenigde Staten: Semax — Niet goedgekeurd, Teduglutid — Op recept. These are factual summaries with source and review date on the individual pages.