Vergelijking

Sincalide vs. Terlipressin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

25126-32-3

14636-12-5

Molecuulmassa

1143.29 g/mol

1227.37 g/mol

Halfwaardetijd

geen gegevens

Sequentie

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

geen gegevens

Werkingsmechanisme

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Terlipressin

Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.

Bewijsbasis

Hoogste bewijs

Humane studie

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Sincalide	Terlipressin
Duitsland	Onduidelijk	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Sincalide

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Terlipressin

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Frequently asked questions

What is the difference between Sincalide and Terlipressin?: Sincalide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Sincalide or Terlipressin?: The highest available evidence level is "Humane studie" for Sincalide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Sincalide and Terlipressin in Germany and the United States?: Duitsland: Sincalide — Onduidelijk, Terlipressin — Op recept. Verenigde Staten: Sincalide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Sincalide

Terlipressin

Duitsland

Onduidelijk

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Sincalide and Terlipressin?

Sincalide is classified as "Onderzoek (overig)", while Terlipressin is classified as "Onderzoek (overig)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Sincalide or Terlipressin?

The highest available evidence level is "Humane studie" for Sincalide and "Humane RCT" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Sincalide and Terlipressin in Germany and the United States?

Duitsland: Sincalide — Onduidelijk, Terlipressin — Op recept. Verenigde Staten: Sincalide — Op recept, Terlipressin — Op recept. These are factual summaries with source and review date on the individual pages.