Сравнение
Ipamorelin vs. Sermorelin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Рост
Рост
Номер CAS
170851-70-4
86168-78-7
Молекулярная масса
711.86 g/mol
3358 g/mol
Период полувыведения
2 h
0.2 h
Последовательность
Aib-His-D-2-Nal-D-Phe-Lys-NH2YADAIFTNSYRKVLGQLSARKLLQDIMSRМеханизм действия
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
4
5
из них на людях
3
3
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
1
3
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Ipamorelin and Sermorelin?
- Ipamorelin is classified as "Рост", while Sermorelin is classified as "Рост". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Ipamorelin or Sermorelin?
- The highest available evidence level is "РКИ на людях" for Ipamorelin and "РКИ на людях" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Ipamorelin and Sermorelin in Germany and the United States?
- Германия: Ipamorelin — Не одобрено, Sermorelin — Не одобрено. США: Ipamorelin — Не одобрено, Sermorelin — Только для исследований. These are factual summaries with source and review date on the individual pages.