Comparison
Ipamorelin vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
170851-70-4
86168-78-7
Molecular weight
711.86 g/mol
3358 g/mol
Half-life
2 h
0.2 h
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2YADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Ipamorelin
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
4
5
of which in humans
3
3
Effects recorded
3
3
Open conflicts
1
1
Documented adverse events
1
3