Confronto

Ipamorelin vs. Sermorelin

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Crescita

N. CAS

170851-70-4

86168-78-7

Peso molecolare

711.86 g/mol

3358 g/mol

Emivita

2 h

0.2 h

Sequenza

Aib-His-D-2-Nal-D-Phe-Lys-NH2

YADAIFTNSYRKVLGQLSARKLLQDIMSR

Meccanismo d'azione

Ipamorelin

Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.

Sermorelin

Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.

Base di evidenze

Evidenza più alta

RCT sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Ipamorelin	Sermorelin
Germania	Non approvato	Non approvato
Stati Uniti	Non approvato	Solo ricerca

Voci complete

Frequently asked questions

What is the difference between Ipamorelin and Sermorelin?: Ipamorelin is classified as "Crescita", while Sermorelin is classified as "Crescita". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Ipamorelin or Sermorelin?: The highest available evidence level is "RCT sull'uomo" for Ipamorelin and "RCT sull'uomo" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Ipamorelin and Sermorelin in Germany and the United States?: Germania: Ipamorelin — Non approvato, Sermorelin — Non approvato. Stati Uniti: Ipamorelin — Non approvato, Sermorelin — Solo ricerca. These are factual summaries with source and review date on the individual pages.

Country

Ipamorelin

Sermorelin

Germania

Non approvato

Stati Uniti

Non approvato

Solo ricerca

Frequently asked questions

What is the difference between Ipamorelin and Sermorelin?

Ipamorelin is classified as "Crescita", while Sermorelin is classified as "Crescita". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Ipamorelin or Sermorelin?

The highest available evidence level is "RCT sull'uomo" for Ipamorelin and "RCT sull'uomo" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Ipamorelin and Sermorelin in Germany and the United States?

Germania: Ipamorelin — Non approvato, Sermorelin — Non approvato. Stati Uniti: Ipamorelin — Non approvato, Sermorelin — Solo ricerca. These are factual summaries with source and review date on the individual pages.