Vergelijking

Ipamorelin vs. Sermorelin

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Groei

CAS-nr.

170851-70-4

86168-78-7

Molecuulmassa

711.86 g/mol

3358 g/mol

Halfwaardetijd

2 h

0.2 h

Sequentie

Aib-His-D-2-Nal-D-Phe-Lys-NH2

YADAIFTNSYRKVLGQLSARKLLQDIMSR

Werkingsmechanisme

Ipamorelin

Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher; ACTH, cortisol and prolactin are not significantly stimulated in clinical studies. This selectivity was the main reason for its development over older GHRPs.

Sermorelin

Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.

Bewijsbasis

Hoogste bewijs

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Ipamorelin	Sermorelin
Duitsland	Niet goedgekeurd	Niet goedgekeurd
Verenigde Staten	Niet goedgekeurd	Alleen onderzoek

Volledige vermeldingen

Ipamorelin

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Sermorelin

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Frequently asked questions

What is the difference between Ipamorelin and Sermorelin?: Ipamorelin is classified as "Groei", while Sermorelin is classified as "Groei". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Ipamorelin or Sermorelin?: The highest available evidence level is "Humane RCT" for Ipamorelin and "Humane RCT" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Ipamorelin and Sermorelin in Germany and the United States?: Duitsland: Ipamorelin — Niet goedgekeurd, Sermorelin — Niet goedgekeurd. Verenigde Staten: Ipamorelin — Niet goedgekeurd, Sermorelin — Alleen onderzoek. These are factual summaries with source and review date on the individual pages.

Country

Ipamorelin

Sermorelin

Duitsland

Niet goedgekeurd

Verenigde Staten

Niet goedgekeurd

Alleen onderzoek

Frequently asked questions

What is the difference between Ipamorelin and Sermorelin?

Ipamorelin is classified as "Groei", while Sermorelin is classified as "Groei". Ipamorelin: Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus). Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Ipamorelin or Sermorelin?

The highest available evidence level is "Humane RCT" for Ipamorelin and "Humane RCT" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Ipamorelin and Sermorelin in Germany and the United States?

Duitsland: Ipamorelin — Niet goedgekeurd, Sermorelin — Niet goedgekeurd. Verenigde Staten: Ipamorelin — Niet goedgekeurd, Sermorelin — Alleen onderzoek. These are factual summaries with source and review date on the individual pages.