Сравнение

Sincalide vs. Teduglutid

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

25126-32-3

197922-42-2

Молекулярная масса

1143.29 g/mol

3752.13 g/mol

Период полувыведения

нет данных

Последовательность

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

нет данных

Механизм действия

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Teduglutid

Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.

Доказательная база

Наивысшая доказательность

Исследование на людях

РКИ на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Sincalide	Teduglutid
Германия	Неясно	Рецептурный
США	Рецептурный	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Sincalide and Teduglutid?: Sincalide is classified as "Исследования (прочее)", while Teduglutid is classified as "Исследования (прочее)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Sincalide or Teduglutid?: The highest available evidence level is "Исследование на людях" for Sincalide and "РКИ на людях" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Sincalide and Teduglutid in Germany and the United States?: Германия: Sincalide — Неясно, Teduglutid — Рецептурный. США: Sincalide — Рецептурный, Teduglutid — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Sincalide

Teduglutid

Германия

Неясно

Рецептурный

США

Рецептурный

Frequently asked questions

What is the difference between Sincalide and Teduglutid?

Sincalide is classified as "Исследования (прочее)", while Teduglutid is classified as "Исследования (прочее)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Sincalide or Teduglutid?

The highest available evidence level is "Исследование на людях" for Sincalide and "РКИ на людях" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Sincalide and Teduglutid in Germany and the United States?

Германия: Sincalide — Неясно, Teduglutid — Рецептурный. США: Sincalide — Рецептурный, Teduglutid — Рецептурный. These are factual summaries with source and review date on the individual pages.