Comparison
Sincalide vs. Teduglutid
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
25126-32-3
197922-42-2
Molecular weight
1143.29 g/mol
3752.13 g/mol
Half-life
no data
no data
Sequence
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2no data
Mechanism of action
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
0
2
of which in humans
0
2
Effects recorded
1
2
Open conflicts
0
0
Documented adverse events
1
2
Legal status
Full entries
Frequently asked questions
- What is the difference between Sincalide and Teduglutid?
- Sincalide is classified as "Research other", while Teduglutid is classified as "Research other". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Sincalide or Teduglutid?
- The highest available evidence level is "Human trial" for Sincalide and "Human RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Sincalide and Teduglutid in Germany and the United States?
- Germany: Sincalide — Unclear, Teduglutid — Prescription. United States: Sincalide — Prescription, Teduglutid — Prescription. These are factual summaries with source and review date on the individual pages.