Vergelijking

Sincalide vs. Teduglutid

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Onderzoek (overig)

CAS-nr.

25126-32-3

197922-42-2

Molecuulmassa

1143.29 g/mol

3752.13 g/mol

Halfwaardetijd

geen gegevens

Sequentie

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

geen gegevens

Werkingsmechanisme

Sincalide

Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).

Teduglutid

Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.

Bewijsbasis

Hoogste bewijs

Humane studie

Humane RCT

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Sincalide	Teduglutid
Duitsland	Onduidelijk	Op recept
Verenigde Staten	Op recept	Op recept

Volledige vermeldingen

Sincalide

Volledige vermelding →

Teduglutid

Volledige vermelding →

Frequently asked questions

What is the difference between Sincalide and Teduglutid?: Sincalide is classified as "Onderzoek (overig)", while Teduglutid is classified as "Onderzoek (overig)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Sincalide or Teduglutid?: The highest available evidence level is "Humane studie" for Sincalide and "Humane RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Sincalide and Teduglutid in Germany and the United States?: Duitsland: Sincalide — Onduidelijk, Teduglutid — Op recept. Verenigde Staten: Sincalide — Op recept, Teduglutid — Op recept. These are factual summaries with source and review date on the individual pages.

Country

Sincalide

Teduglutid

Duitsland

Onduidelijk

Op recept

Verenigde Staten

Op recept

Frequently asked questions

What is the difference between Sincalide and Teduglutid?

Sincalide is classified as "Onderzoek (overig)", while Teduglutid is classified as "Onderzoek (overig)". Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Sincalide or Teduglutid?

The highest available evidence level is "Humane studie" for Sincalide and "Humane RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Sincalide and Teduglutid in Germany and the United States?

Duitsland: Sincalide — Onduidelijk, Teduglutid — Op recept. Verenigde Staten: Sincalide — Op recept, Teduglutid — Op recept. These are factual summaries with source and review date on the individual pages.