Abaloparatide is a synthetic 34-amino-acid analogue of parathyroid hormone-related protein (PTHrP 1-34). It is regulatory-approved and studied in the scientific literature as a bone-anabolic agent for the treatment of osteoporosis in postmenopausal women at high fracture risk. Like the related teriparatide, studies describe it as stimulating new bone formation, but it exhibits a distinct receptor-binding profile.
Abaloparatide is a synthetic analogue of the first 34 amino acids of parathyroid hormone-related protein (PTHrP). Like parathyroid hormone and teriparatide it binds the PTH-1 receptor, but the literature describes it as preferentially engaging the so-called RG conformation of the receptor, which is associated with shorter signaling duration. As for the entire drug class, intermittent receptor activation is regarded as the mechanistic basis for the stimulation of bone-forming osteoblasts observed in studies, whereas continuously elevated exposure would tend to favor bone resorption. From this binding behavior the literature derives a discussed balance between bone formation and bone resorption.
Теоретическая кривая концентрации при периоде полувыведения 1.7 h. Чисто фармакокинетическая модель — не рекомендация по дозировке.
Open in PK tool →Пептиды поставляются в виде сухого порошка. После растворения в жидкости (восстановление) этот калькулятор отвечает на единственный вопрос: сколько вещества содержится в одном миллилитре раствора после этого?
Эти сопутствующие вещества относятся к классу пептида, а не к конкретному применению. Без рекомендаций, без дозировки.
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