Family
Crecimiento
Peptides acting on the growth-hormone system or the IGF axis.
Structures that interact with the growth-hormone-releasing system or act as secretagogues. Evidence is mixed — pharmacokinetics and endogenous response vary considerably between substances.
This overview is editorial. It describes the evidence base, not a usage recommendation.
Members
12 entries in this familyAOD-9604
ECA en humanos3 studies · 3 observations
AOD-9604 corresponds to the C-terminal fragment 176-191 of human growth hormone with an additional N-terminal tyrosine. In animal models, lipolytic effects with…
CJC-1295
Estudio en humanos4 studies · 3 observations
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the…
Follistatin (FST)
Estudio en humanos4 studies · 4 observations
Follistatin binds with high affinity to activin and to myostatin (GDF-8), as well as related TGF-β ligands such as GDF-11 and some BMPs, preventing their bindin…
GHRP-2
Estudio en humanos4 studies · 3 observations
GHRP-2 binds with high affinity to the GH secretagogue receptor (GHSR-1a) in the pituitary and hypothalamus. Activation leads to rapid release of pulsatile grow…
GHRP-6
Estudio en humanos4 studies · 4 observations
GHRP-6 is a high-affinity agonist of the growth-hormone secretagogue receptor 1a (GHSR-1a) — the same receptor later shown to bind the endogenous hormone ghreli…
Hexarelin
Estudio en humanos4 studies · 3 observations
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pul…
IGF-1 LR3
Modelo animal4 studies · 4 observations
IGF-1 LR3 is a recombinantly produced variant of human IGF-1. Two changes define its properties: (1) at position 3, glutamic acid is replaced by arginine; (2) a…
Ipamorelin
ECA en humanos4 studies · 3 observations
Ipamorelin is a selective agonist at the GH secretagogue receptor (GHSR-1a). Compared to GHRP-2 and GHRP-6 its selectivity for the growth-hormone axis is higher…
MGF (Mechano Growth Factor)
Modelo animal4 studies · 3 observations
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved fr…
Mod GRF (1-29)
Estudio en humanos4 studies · 3 observations
Synthetic analogue of the first 29 amino acids of growth-hormone-releasing hormone (GHRH 1-29). Four amino-acid substitutions (D-Ala at position 2, Gln at 8, Al…
Sermorelin
ECA en humanos5 studies · 3 observations
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from t…
Tesamorelin
ECA en humanos4 studies · 3 observations
Tesamorelin is an N-terminally modified 44-amino-acid version of human GHRH(1-44). A 3-hexenoyl modification protects against rapid dipeptidyl-peptidase-IV clea…