Vergelijking

Argireline vs. GHK-Cu

Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.

Identiteit

Categorie

Cosmetisch

CAS-nr.

616204-22-9

49557-75-7

Molecuulmassa

888.99 g/mol

340.4 g/mol

Halfwaardetijd

geen gegevens

Sequentie

Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2

GHK

Werkingsmechanisme

Argireline

Argireline is a synthetic hexapeptide whose sequence corresponds to the N-terminus of the SNAP-25 protein. In vitro it has been shown to competitively inhibit SNARE complex formation (necessary for vesicle fusion in neurotransmitter release). Topical application is intended — given very limited skin permeation — to attenuate cholinergic signalling at the neuromuscular endplate. The effect is orders of magnitude weaker than intramuscular botulinum toxin; the clinical translatability of the in-vitro observations to the skin microenvironment is contested.

GHK-Cu

Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.

Bewijsbasis

Hoogste bewijs

Humane studie

Studies

waarvan bij mensen

Geregistreerde effecten

Openstaande tegenstrijdigheden

Gedocumenteerde bijwerkingen

Juridische status

Country	Argireline	GHK-Cu
Zwitserland	—	Niet goedgekeurd
Duitsland	Niet goedgekeurd	Niet goedgekeurd
EU	Niet goedgekeurd	—
Verenigde Staten	Niet goedgekeurd	Niet goedgekeurd

Volledige vermeldingen

Argireline

Volledige vermelding →

GHK-Cu

Volledige vermelding →

Frequently asked questions

What is the difference between Argireline and GHK-Cu?: Argireline is classified as "Cosmetisch", while GHK-Cu is classified as "Cosmetisch". Argireline: Synthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking action of botulinum toxin, but with substantially lower potency and without intramuscular effect. EU-compliant as a cosmetic ingredient (CosIng), not approved as a medicine. GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Argireline or GHK-Cu?: The highest available evidence level is "Humane studie" for Argireline and "Humane studie" for GHK-Cu. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Argireline and GHK-Cu in Germany and the United States?: Duitsland: Argireline — Niet goedgekeurd, GHK-Cu — Niet goedgekeurd. Verenigde Staten: Argireline — Niet goedgekeurd, GHK-Cu — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.

Country

Argireline

GHK-Cu

Zwitserland

—

Niet goedgekeurd

Duitsland

Niet goedgekeurd

—

Verenigde Staten

Niet goedgekeurd

Frequently asked questions

What is the difference between Argireline and GHK-Cu?

Argireline is classified as "Cosmetisch", while GHK-Cu is classified as "Cosmetisch". Argireline: Synthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking action of botulinum toxin, but with substantially lower potency and without intramuscular effect. EU-compliant as a cosmetic ingredient (CosIng), not approved as a medicine. GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Argireline or GHK-Cu?

The highest available evidence level is "Humane studie" for Argireline and "Humane studie" for GHK-Cu. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Argireline and GHK-Cu in Germany and the United States?

Duitsland: Argireline — Niet goedgekeurd, GHK-Cu — Niet goedgekeurd. Verenigde Staten: Argireline — Niet goedgekeurd, GHK-Cu — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.