Comparison
Argireline vs. GHK-Cu
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Cosmetic
CAS no.
616204-22-9
49557-75-7
Molecular weight
888.99 g/mol
340.4 g/mol
Half-life
no data
no data
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2GHKMechanism of action
Argireline
Argireline is a synthetic hexapeptide whose sequence corresponds to the N-terminus of the SNAP-25 protein. In vitro it has been shown to competitively inhibit SNARE complex formation (necessary for vesicle fusion in neurotransmitter release). Topical application is intended — given very limited skin permeation — to attenuate cholinergic signalling at the neuromuscular endplate. The effect is orders of magnitude weaker than intramuscular botulinum toxin; the clinical translatability of the in-vitro observations to the skin microenvironment is contested.
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
5
of which in humans
3
2
Effects recorded
3
4
Open conflicts
1
1
Documented adverse events
1
2
Legal status
Full entries
Frequently asked questions
- What is the difference between Argireline and GHK-Cu?
- Argireline is classified as "Cosmetic", while GHK-Cu is classified as "Cosmetic". Argireline: Synthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking action of botulinum toxin, but with substantially lower potency and without intramuscular effect. EU-compliant as a cosmetic ingredient (CosIng), not approved as a medicine. GHK-Cu: Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Argireline or GHK-Cu?
- The highest available evidence level is "Human trial" for Argireline and "Human trial" for GHK-Cu. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Argireline and GHK-Cu in Germany and the United States?
- Germany: Argireline — Unapproved, GHK-Cu — Unapproved. United States: Argireline — Unapproved, GHK-Cu — Unapproved. These are factual summaries with source and review date on the individual pages.