Vergelijking
CJC-1295 vs. MGF (Mechano Growth Factor)
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Groei
Groei
CAS-nr.
geen gegevens
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
Molecuulmassa
3647.3 g/mol
2867.2 g/mol
Halfwaardetijd
144 h
0.1 h
Sequentie
YADAIFTNSYRKVLGQLSARKLLQDIMSR-DACYQPPSTNKNTKSQRRKGSTFEERKWerkingsmechanisme
CJC-1295
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the pituitary GHRH receptor and stimulates endogenous growth-hormone release.
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Bewijsbasis
Hoogste bewijs
Humane studie
Diermodel
Studies
4
4
waarvan bij mensen
3
0
Geregistreerde effecten
3
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
3
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between CJC-1295 and MGF (Mechano Growth Factor)?
- CJC-1295 is classified as "Groei", while MGF (Mechano Growth Factor) is classified as "Groei". CJC-1295: Long-acting synthetic GHRH analogue modified for albumin binding (DAC). Stimulates endogenous growth-hormone release. Pharmacodynamic effect established in small human studies; clinical endpoint trials are missing. MGF (Mechano Growth Factor): Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, CJC-1295 or MGF (Mechano Growth Factor)?
- The highest available evidence level is "Humane studie" for CJC-1295 and "Diermodel" for MGF (Mechano Growth Factor). A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of CJC-1295 and MGF (Mechano Growth Factor) in Germany and the United States?
- Duitsland: CJC-1295 — Niet goedgekeurd, MGF (Mechano Growth Factor) — Niet goedgekeurd. Verenigde Staten: CJC-1295 — Alleen onderzoek, MGF (Mechano Growth Factor) — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.