Vergelijking
Epitalon vs. Teduglutid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
307297-39-8
197922-42-2
Molecuulmassa
390.35 g/mol
3752.13 g/mol
Halfwaardetijd
0.3 h
geen gegevens
Sequentie
Ala-Glu-Asp-Glygeen gegevens
Werkingsmechanisme
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Bewijsbasis
Hoogste bewijs
Humane studie
Humane RCT
Studies
4
2
waarvan bij mensen
1
2
Geregistreerde effecten
4
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
1
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Epitalon and Teduglutid?
- Epitalon is classified as "Onderzoek (overig)", while Teduglutid is classified as "Onderzoek (overig)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Teduglutid?
- The highest available evidence level is "Humane studie" for Epitalon and "Humane RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Teduglutid in Germany and the United States?
- Duitsland: Epitalon — Niet goedgekeurd, Teduglutid — Op recept. Verenigde Staten: Epitalon — Niet goedgekeurd, Teduglutid — Op recept. These are factual summaries with source and review date on the individual pages.