Vergelijking
Exenatide vs. Pemvidutide
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
141758-74-9
geen gegevens
Molecuulmassa
4186.6 g/mol
geen gegevens
Halfwaardetijd
2.4 h
geen gegevens
Sequentie
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSgeen gegevens
Werkingsmechanisme
Exenatide
Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV cleavage and extends the half-life from native GLP-1 (minutes) to about 2.4 hours. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon and delays gastric emptying.
Pemvidutide
The GLP-1 component suppresses appetite while the glucagon component raises energy expenditure and acts directly on hepatic fat metabolism — the combination is intended to mimic the complementary effects of diet and exercise.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
5
1
waarvan bij mensen
4
1
Geregistreerde effecten
3
2
Openstaande tegenstrijdigheden
1
0
Gedocumenteerde bijwerkingen
2
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Exenatide and Pemvidutide?
- Exenatide is classified as "Metabool", while Pemvidutide is classified as "Metabool". Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. Pemvidutide: Pemvidutide is a 29-amino-acid GLP-1/glucagon dual receptor agonist (Altimmune) under investigation for obesity and the fatty-liver disease MASH. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Exenatide or Pemvidutide?
- The highest available evidence level is "Humane RCT" for Exenatide and "Humane studie" for Pemvidutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Exenatide and Pemvidutide in Germany and the United States?
- Duitsland: Exenatide — Op recept, Pemvidutide — Niet goedgekeurd. Verenigde Staten: Exenatide — Op recept, Pemvidutide — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.